Sandhills Community College Alexander the Great Re Essays - Film

Sandhills Community College Alexander the Great Re Essays - Film Sandhills Community College Alexander the Great Research Paper Shianne Buie Professor Leake HIS 111-SN 1 April sixteenth, 2017 Famous writer William Shakespeare once composed , S ome men are brought into the world extraordinary, some accomplish significance, and o thers have enormity pushed onto them . In numerous manners, Alexander III of Macedon falls into each of the three of those classes. (History Channel) During a mind-blowing course Alexander was loaded up with striking accomplishments and today is known as one of the most essential rulers ever. Because of his noteworthy extension of the Greek domain, honorable instinct as a legislator and th e l oyalty he roused in his men , Alexander the Great has earned himself the title as one of the most cultivated pioneers ever. Alexander III was conceived at some point in July of 356 BC to the leaders of Macedonia, King Phillip II and his significant other Olympias who, alongside the whole realm, had exceptionally high trusts in the k id. While the ruler would without a doubt proceed to be perceived as one of the best military prodigies ever and accumulate the biggest domain the old world had ever observed, he required some direction first. From the time he was youthful, Alexander was being prepared to one day assume control over the realm thus he spent a significant decent measure of his adolescence in the organization of mentors. He was instructed how to battle, ride like any future officer but at the same time was taught in subjects, for example, s cience, writing and theory by none of than the popular scholar Aristotle. Having this man as his instructor opened the ruler ' s brain to incalculable prospects and trusts in his future. There is in reality valid justification to accept that the savants lessons are a piece of the explanation for Alexander ' s steady want for the extension of his own domain. In spite of the fact that the matter of condition did likewise have an enormous impact in the arrangement of o ccasions that would come upon him throughout everyday life. At the point when the sovereign was only nineteen his dad, Phillip II, was killed by his guardian chief at a banquet for his little girls wedding. Alexander himself burned through no time in picking up the help he expected to guarantee the seat and once he had the sponsorship of the commanders and troops he had once battled close by, he was declared ruler. Despite the fact that still very youthful, the adolescent had just demonstrated himself to be more than fit for protecting the realm in his dads nonattendance so most had no issue tolerating him as lord. Not long after rising the seat, Alexander began on the triumph of the Persian Empire, which would get remembered perhaps the best accomplishment. Having the option to oust a domain as solid as Persia was no little feet, Alexander must be a gifted strategist, canny and have steadfast soldiers with the end goal for everything to work out. On the off chance that he had been inadequate in any of these zones, at that point the whole fight may have gone an alternate way and the world we realize today might've been totally unique. Fortunately the youthful ruler had all the devices important to prevail in this undertaking and the result ended up in support of himself. Since Persia had consistently been savage opponent of Greece, Alexander increased significantly more kindness with his kin once he declared himself the new lord in the wake of vanquishing all the contradicting powers. He would then proceed to topple Asia Minor, Egypt, India, Mesopotamia and different innumerable domains. The reality the Alexander figured out how to achieve such a great amount in just thirteen years as ruler exhibits simply was a mind blowing pioneer he was. So as to vanquish such a significant number of domains, all while guaranteeing his recently discovered subjects were content and never truly endeavored to revolt, Alexander must be a really skilled government official. Pres ently in many pieces of history once a country had been assumed control over, their way of life turned into everything except lost, their religions were prohibited and the residents were typically rewarded unfeelingly, some of the time they were even killed. Anyway this wasn't the situation with Alexander, he appeared to grasp the changed societies of each land he vanquished and even joined a few viewpoints into his own. Obviously the

Compare and contrast the 2 poems Essay Example For Students

Investigate the 2 sonnets Essay Both On my first Sonne and outcast mother and kid manage the passing of a kid. Investigate the 2 sonnets, investigating their subjects and thoughts, the artists utilization of language and your own response to them. The Poems On My First Sonne Farewell, thou offspring of my correct hand, and satisfaction; My sinne was an excess of any expectation of thee, lovd kid, Seven yeeres thowert loaned to me, and I thee pay, Exacted by thy destiny, on the only day. O, might I be able to free all dad, presently. For what reason Will man mourn the state he ought to envie? To have so soone scapd universes, and fleshes rage. What's more, if no other miserie, yet age? Rest in delicate harmony, and, askd, state here both lye BEN JONSON his best bit of poetrie. For whose purpose, subsequently forward, all his vowes be such. As what he adores may never like excessively. Ben Jonson Refugee Mother and Child No Madonna and Child could contact that image of a moms delicacy for a child she before long would need to overlook. The air was substantial with smells of looseness of the bowels of unwashed kids with cleaned out ribs and evaporated bottoms battling in toiled ventures behind blown void guts. Most moms there had since quite a while ago stopped to mind yet not this one; she held a phantom grin between her teeth and in her eyes the apparition of a moms pride as she brushed the rust-shaded hair left on his skull and afterward singing in her eyes started cautiously to part it In another life this probably been a little every day demonstration of no result before his morning meal and school; presently she did it like putting blossoms on a minuscule grave. Chinua Achebe Background on Ben Jonson Ben Jonson was conceived on the eleventh of June, 1572. He was instructed at Westminster School by William Camden and worked his stepfathers exchange, bricklaying. Jonson joined the military, disappointed with his activity, serving in Flanders. He came back to England in 1592 and wedded Anne Lewis on November fourteenth, 1595. Ben Jonson joined the showy organization of Philip Henslow as an on-screen character and a dramatist at around 1595. In 1597 Jonson was captured for his association in a parody entitled The Isle of Dogs. This was announced subversive by the specialists. After a year Jonson slaughtered a kindred entertainer. His name was Gabriel Spencer. Jonson murdered him in a duel in the Fields at Shoreditch. Foundation on Chinua Achebe Chinua Achebe was conceived in eastern Nigeria. He began his training at a congregation preacher society school. His optional and college trainings were likewise in Nigeria. He moved on from University College, Ibadan, in 1953. At that point, he worked for more than ten years for the Nigerian Broadcasting Company. He left the N. B. C. in 1966 and set out toward a profession recorded as a hard copy and instructing. Achebe assumed a critical job in the advancement of the Heinemann African Writers Series, an arrangement which has given numerous Africans a voice in the western world and which, outside of Africa, distributes progressively African (and Caribbean) scholars than some other distributing house.

The disscussion of the conceptual framework Essay

The disscussion of the applied system - Essay Example The IASB’s primary job is to help global clients to structure a worldwide system for the readiness and introduction of budgetary report, a job that has throughout the years confronted significant analysis because of the shortcomings in the destinations and the ideas that it depends on. The Framework is created to address the central purpose behind the nearness of the budget summaries, which is to give valuable money related data about the revealing substance to all the related gatherings (financial specialists, loan specialists, different leasers) for settling on choices about giving assets to the element. The substance of the Framework are focal around the five components from which budget summaries are built. This paper targets distinguishing and examining the execution of the IASB’s calculated structure dependent on its hands-on destinations for the most part that of giving a premise to managerial standard-setting and settling bookkeeping discussions in thought layou t to the bookkeeping ideas, standards and core interest. The paper is composed into three areas; the principal segment clarifies the ideas, goals and focal point of the IASB’s applied system, the subsequent segment portrays the shortcomings and the premise of the analysis confronting the IASB structure while the third segment is a decision, rundown and a conversation of the analysis confronting the current IASB’s conversation paper. As expressed, the IASB’s structure sets ideas that shape how fiscal summaries are arranged and introduced for outer clients. The IASB system needs bookkeeping standard status in contrast with the announcement of standards got from the United Kingdom Accounting Standards Board (ASB). The IASB structure contains seven fragments that spread territories, for example, targets of money related detailing, the basic suppositions, Qualitative highlights of monetary data, the major guidelines of budgetary

Essay on The Business Environment at Mcdonalds - 2230 Words

Contents Page: Table of Contents Contents Page: 2 Introduction 3 Choosing an Organization 3 Brief introduction to McDonalds 4 Aims of the Report 4 SAFE Framework 5 Strategic option 1 6 Frozen Foods 6 Strategic Option 2 11 McDonalds in a Supermarket 11 Strategic Option 3 15 McCafe 15 Conclusion 19 References 20 Appendices 21 Introduction Choosing an Organization McDonalds was chosen to be the organization as a group decision. The reason being that it was an organization recognized all over the world, having a high profile and a strong iconic brand. Given the size of the organization, it was decided that there are a lot of strategic options available to McDonalds. Brief introduction to McDonalds McDonalds was†¦show more content†¦These 3 strategic options selected by the group have been individually examined and evaluated using the framework SAFE, developed by Johnson Scholes (2008). SAFE would be used to assess whether the strategies are Suitable, Acceptable and Feasible. Looking at the evaluation of the 3 strategies using SAFE would allow identifying and determining the chosen strategic option for McDonalds. The 3 strategies are shown in figure 1: (Figure 1) SAFE Framework To evaluate the 3 strategic options the SAFE framework would be used, below explains how the SAFE framework works and what each of the stages mean: Johnson, Scholes and Whittington argue that for a strategy to be successful it must satisfy three criteria shown in figure 2 (Kfknowledgebank.kaplan.co.uk, 2014): †¢ (Figure 2) (Kfknowledgebank.kaplan.co.uk, 2014) Strategic option 1 Frozen Foods The first option available to McDonalds is frozen foods. This option would allow McDonalds to enter a new market, thus leading to potentially increasing their profit margins. Since McDonalds are successfully established, consumers may not hesitate to buy the McDonalds product frozen at their local supermarket, as this would give them a choice and time period of when they can cook it. An article from the Guardian mentions, ‘sales of frozen food have increased and more upmarket options have become available’ (Hardwick, 2014). This statement shows how McDonalds canShow MoreRelatedMcdonald Business Environment906 Words   |  4 PagesIntroduction McDonald Corporation is the world’s largest chain of hamburger fast food restaurant. There are over 30,000 McDonald’s restaurants in more than 100 countries and served an average of 50 million customer daily. A McDonald restaurant is operated by either a franchisee or by the corporation itself. The very first McDonald was open in Singapore in 1979 and today there are over 120 McDonald restaurants across the island which served 1.2 million customers weekly. McDonald employs around 9Read MoreMcdonald s The Best Food Retail Brand Of The World Essay1222 Words   |  5 PagesSumanpreet Introduction McDonald is one of the best food retail brand in the world. McDonald have almost 35000 locations worldwide and caters approximately 70 million consumers. Most of the McDonald outlets are independently owned by local business persons. McDonald has been providing sustainable supply chain to ensure benefit to its supplier as well as distributors to maximise profit.in addition to this MacDonald continuously working with charity foundations and provide sponsorships for events toRead MoreMcdonald s Strength And Weakness1280 Words   |  6 PagesAbstract McDonalds is considered to be the world’s largest and most globally known fast food restaurant, which serves approximately 69 million consumers daily. This report will evaluate McDonald’s strength and weakness in terms of their ethical claims. The main aim of this report is to consider the reasons why McDonalds has been criticized by most of its consumers in terms of its pollution to its environment and the destruction natural rain forest, furthermore this report will discuss the nutritionRead MoreCorporate Social Responsibility : Mcdonald s The World s Largest Chain Of Hamburger Fast Food Restaurants1014 Words   |  5 Pagesthis statement. CSR (Corporate Social Responsibility) is a form of self-regulation integrated into a business model whereby companies and enterprises consider the interest of society by taking responsibility of many objects such as employees, shareholders, customers, even communities and environment. President CEO of McDonald s corporation Mr.Don Thompson has stated : â€Å"We realise that our business and responsibilities to society are inextricably linked.† In fact, this firm has worked diligentlyRead MorePestle Analysis Of Mcdonalds1628 Words   |  7 PagesPESTLE analysis PESTLE is the analysis of the factors that could affect a business on a macro level. McDonalds franchise strategizes issues identified in this PESTLE analysis. The PESTLE analysis model determines the different external factors that offers opportunities or threats to the business based on its macro-environment. In the global fast food restaurant market, McDonalds is focused on economic and sociocultural factors. Nonetheless, the company’s success is indicative of its effective strategiesRead MoreHuman Resource Planning and Development Leads to Success Essay examples1396 Words   |  6 Pagesconcept can be attributed to the establishment of apprenticeship programs in the 18th Century (Werner DeSimone, 2011, p.5). The significance of human resource development in today’s business environment is attributed to its role in organizational profitability. Human resource planning involves the use of business activities to forecast how management strategy changes will impact human resource needs in the future. On the contrary, human resource development activities help an organization to ensureRead MoreMcdonalds Porters Five Forces Model Essay1184 Words   |  5 PagesAnalysing McDonalds (fast food outlets) using Porters 5 Forces model – sometimes called the Competitive Forces model. Introduction McDonalds Canada opened in 1967, thirteen years after McDonalds had taken the United States by storm. This was the first restaurant to be opened outside of the United States. It was in 1965 that McDonalds went public and offered shares on Wall Street. Since then it has been important for McDonalds to continually monitor its performance, to make sure it is competitiveRead MoreEssay about Organizational Structure- Mgt/2301127 Words   |  5 Pages The central thesis of this paper examines the organizational structures of McDonalds, Burger King, and Wendy’s food restaurants. It will examine the comparison and contrast of the organizational structure of McDonalds with Burger King, and Wendy’s Corporations. What functions influence McDonalds, and explains how the organizational design helps determine the structure that best suits McDonalds needs, as a business. Organizational Structure Burgers are one of the most favored junk foodsRead MoreThe Marketing Environment, Consumer Markets, The Worlds Largest Fast Food Chain And His Presence1214 Words   |  5 Pagesorganization as McDonalds. I will make particular reference of the marketing environment, consumer markets, market segmentation and the importance of the role of the marketing mix. In addition, I will focus on the concepts of marketing in terms of supporting their brand standards. McDonalds is known as the world s largest fast food chain and his presence is global. McDonald s has over 25,000 restaurants in the world., The organization, founded in 1940 by Richard and Maurice McDonald, has now operatingRead MoreMcdonald s Of New Zealand Essay1648 Words   |  7 PagesCompany Background And History Here I choose a McDonald s of New Zealand for my assignment. I choose this organization because it is very up growing organization of New Zealand. The biggest reason for choosing this organization is that because I am working here and I know much more about that. It all began in the USA in 1954 with a milkshake machine salesman named Ray Kroc. Ray received an order from the McDonald brothers hamburger outlet in California. He was fascinated by their operation - the

Types of Death Penalty - 1564 Words

â€Å"The death penalty for heinous crime is as justifiable, if society deem it necessary for its well-being, as is the demand upon the citizen-warrior to meet death upon the battle-field, or upon the doctor to remain steadfast at his duty in the plague-stricken city. The good of society is the prime reason for the punishment of criminals and their reformation is justifiable only when it conduces to this end† (Hall, 1902, p. 390). In recent years, death penalty has become a much talked about and controversial issue regardless of nation, culture or race. One of the earliest and known death penalty sentenced would be the crucifixion of Jesus Christ. This proves that death penalty has existed since a long time ago. Globally, death penalty is†¦show more content†¦This form of hanging is not to break the neck of the prisoners; rather letting them die of strangulation. Last of all, the most humane form would be the long drop hanging. The prisoners would be allowed to fall a pre-determined height, then jerked upwards. The prisoners’ neck break easily and immediately as the heads are still attached to the noose; thus, lessening the pain and suffering of the prisoners. Death Penalty Information Center (n.d.) has concluded the process of general hanging. The process is started when the prisoner is weighed a day before the execution and the prison officers rehearse using a bag of sand weighing the same as the prisoner. By rehearsing, the prison officers could determine the length of the rope so as not to prolong the torture and suffering of the prisoner. Before the rope can be used, it has to be treated. Firstly, the 3/4inch to 1  ¼ inch rope is â€Å"boiled and stretched to eliminate spring or coiling. The knot should be lubricated with wax or soap† (â€Å"Hanged by the Neck†, n.d.) â€Å"to ensure a smooth sliding action† (US Army Manual, 1969). Now, the prisoner is blindfolded, hands and legs bounded, and noose is placed on his neck. Then, the trapdoor underneath the prisoner is opened, allowing the prisoner to fall through. Should everything is properly in place, a rapid fracture dislocation of the neck will occur. However, Weisberg (1991) says â€Å"instantaneous death rarely occurs†.Show MoreRelatedTypes Of Punishments That Comes With The Death Penalty918 Words   |  4 Pagesare five different types of punishments that comes with the death penalty. The five methods of the death penalties are Lethal Injection, Gas, electric chair . One thing that I always think of is what each methods has upon the humans body. In this research paper you ll learn what these execution methods does to a human and also the steps these inmates go through when they are sentenced to execution. The first type of execution is the gas chamber . In the gas chamber the type of gas which is dispersesRead MoreShould The Death Penalty Be A Type Of Corporal Punishment?844 Words   |  4 Pagesa serious crime has no severe punishment, the nation should adopt a type of corporal punishment. As adults, we have grown out of spankings from our parents, but that also means that the responsibility for actions has been placed upon our shoulders. Whether it be positive or negative, there is a consequence for every action taken. Therefore, with a negative action a negative consequence should be given. While the death penalty may appear faintly harsh and inhuman, so is the killing of other humansRead MoreThe Death Penalty Is The Most Appropriate Type Of Punishment843 Words   |  4 Pagescommitting an immoral act is the most appropriate type of punishment that should be given to a convicted criminal. The name of this capital punishment is mostly referred to as, The Death Penalty, and it can be presented in different ways. This consists of being vitally shot at by a firing squad, poisoned in a gas chamber, given a lethal injection, and so on. Today in the United States, there are thirty one states that approve of the death penalty, while nineteen states believe it is unethical andRead MoreThe Death Penalty : A Multi Level Analysis Of Public Opinion1179 Words   |  5 PagesIn society, the death penalty is used to punish those who had committed certain types of crimes. Over the years, the percentage of US citizens supporting the death penalty has decrease, however Proximally 64%-70% of the population still support it. The majority of the polls created to evaluate the opinion of citizens on the death penalty use simple questions to address the issue. Those questions separate people into those against it and those supporting it. The death penalty opinion is more complexRead MoreThe Debate Over Death Penalty1618 Words   |  7 PagesReiner Writing 39C 7/20/16 Debates over Death Penalty in the United States The issue of death penalty today is a popular topic for numerous public and scholarly discussions. The death penalty has a long and distinguished history in the United States, as it has been around in some form—either official or otherwise—since the beginning of American society. America originally adopted the British justice system, with hundreds of crimes being punishable by death. Slowly but surely, states began to eliminateRead MoreDeath Penalty Is The Last Legal Resource Of Justice1472 Words   |  6 Pagesrevenge instead of retribution as the main motivating factor. This essay will explore the most credible and valid arguments that justify death penalty as the last legal resource of justice. When I write about something, I am really writing about my point of view. Then, I need to start this essay writing about who criminal really deserve death penalty. For me, death penalty is the last resource of justice, just applicable when criminals: - don’t have regrets - have the tendency to repeat the crime - theRead More Its Time to Abolish the Death Penalty Essay1187 Words   |  5 Pages The death penalty has been around since the beginning of time as a means of punishing criminals, undisputed until the last century or so in terms of whether or not it is an ethical practice. The proponents for the death penalty offer up its ability to deter crime as their main reason for supporting it, their view supported by a functionalist sociological view in that using the death penalty, enough fear will be generated that people will refrain from committing the types of crime that theRead MoreShould The Us Stop Using The Death Penalty?1599 Words   |  7 Pagesusing the death penalty? Capital punishment is a legal authorization to kill someone for a crime they have committed. The death penalty has been the highest form of criminal punishment in the American judicial system since the 13 colonies. It has taken the form of hanging, stoning, drowning, burning, beheading, gassing, electrocution, and injection. The taking of a man s life as penance for criminal behavior is wrong. The moral injustice of murder, the cruelty of execution, and the death of innocentRead MoreBanning the Death Penalty1620 Words   |  6 PagesShould the death penalty be banned internationally as a type of punishment? This form of punishment has been quite a controversial issue worldwide for quite a few years. The death penalty for hundreds of thousands of years has been a punishment for criminals throughout the world; in the past ranging from what we would now consider small crimes to huge ones, to the present where most if not all those punished with death penalty are for fairly large crime s. Actual laws involving death penalty is knownRead MoreThe Debate On The Death Penalty1597 Words   |  7 PagesThe debate on the death penalty has been the ongoing question for generations. There are plenty of different sides to take on this issue. You have the side where some people think that putting prisoners to death is inhumane and that no matter what they did putting a human to death is wrong. While others may think that if the crime is extreme enough that the prisoner who committed this crime should pay for it with their own life. Throughout history there have been several instances where prisoners

George Orwells Style of Writing Essay example - 1038 Words

Just by a simple glance at George Orwells style of writing one can grasp a lot. He first starts the essay by discussing how the narrator was poorly treated in Lower Burma when serving as a police officer. More specifically the narrator states, I was hated by large numbers of people,, and anti-European feeling was very bitter. From there one could interpret that although he was a British soldier with much power he was baited whenever it seemed safe to do so. He then goes into much detail and paints scenes into the readers mind such as how a European woman could not cross the market without having someone spit betel juice over her dress, to create a sense of remorse for the roughly treated Europeans. Furthermore, Orwell creates†¦show more content†¦The narrator then elaborates on his struggle of not making his hatred towards his job obvious; and says I hated it more bitterly than I can perhaps make clear. He even claims that it consisted of the dirty work of Empire at close q uarters. Furthermore, the narrator claims that seeing the convicts and prisoners oppressed him with suffering guilt; which in my opinion makes the reader sympathize for him being part of the British establishment; which restricts him from following his sympathy towards the Burmese. Orwells broad style of writing sways the reader into feeling how oppressed the narrator was to be part of the British establishment in Burma. Moreover, one could sense the narrators guilt of being part of the establishment and on the other hand, how he is forced to stay serene about which clearly symbolizes his lack of freedom. Orwells concise style of writing makes it clear that there was no freedom for the British in Burma whether they held a high position or no position at all. Later on, as the narrator receives a call about the elephant wrecking the bazaar, he arms himself with a Winchester rifle. I believe that a weapon here is used as a sign of the British power; since, they have the weapons unlike the Burmese who had no weapons and were quite helpless against it. As the phone rings, the narrator is put in a complex situationShow MoreRelatedBig Brother Is Watching You Essay880 Words   |  4 Pagesrealizes the true price of freedom as he sacrifices his life to attain it. In 1984 (New American Library, 1950), George Orwell, the author, proficiently integrates short, direct sentences and bleak, elementary vocabulary into his uniquely passive style of writing to thoroughly convey his appalling vision of a totalitarian regime to the reader. George Orwell’s passive style of writing incorporates short, direct sentences that vividly portray the bleakness of Oceania. Orwell conveys the appallingRead MorePolitics and the English Language: George Orwell955 Words   |  4 Pages George Orwell’s article â€Å"Politics and the English Language† gives six rules that authors should follow by to be good writers. After reading the article, one notices how often these rules are broken by authors all the time. George Orwell’s article makes readers question whether or not an author knows how to dictate their own thoughts. By breaking Orwell’s rules, an author loses attachment with a reader, and therefore will be unable to convey their message successfully. George Orwell’s first ruleRead MoreAnalysis Of George Orwell s Dystopia 881 Words   |  4 PagesOne of the most prominent examples of the hot topic today, â€Å"Dystopia†, was a novel written and published in 1949 by Secker and Warburg. Its name being â€Å"1984† by George Orwell. â€Å"Big brother is always watching,† the language the author utilizes drops subtle hints from time to time about what could possibly happen in the real world in near future. 1984 still remains one of the most intense and powerful warning signals about the peril of total government control. TheRead MoreAnimal Farm Literary Analysis710 Words   |  3 PagesGeorge Orwell, a writer of many novels and other literature, one of his most known is Animal Farm.This book is where Orwell’s political style as well as other techniques he used in his writing were used most. Animal Farm is about farm animals who are being neglected by their owner, and they decides to overthrow him and take control of their farm. However, that is only the the outer layer of the story, looking under the surface, this is an allegory detailing the Russian Revolution. The author wroteRead MoreAnalysis Of George Orwell s The Voice Of A Generation 884 Words   |  4 PagesWhat would make a story the voice of a generation? George Orwell’s pieces of writing were the voice of an age due to his style of writing. Orwell follows the principles of imagery, tone and ethos, meanwhile creating his own rules. Orwell weaves these principles together to write two famous stories that are pack ed with ethos and told in great detail. Why give a common man more credibility than an emperor? Orwell’s writing style gives him immense credibility because of the sheer detail, vivid colorRead MorePolitics And Language In Animal Farm, By George Orwell720 Words   |  3 PagesGeorge Orwell was a political writer who made it his life’s goal to expose the injustices he saw in the world. He does this through the many novels and essays he writes. 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Construction, Design and Analysis of a Single

Construction, Design and Analysis of a Single-lesi Essay on Containing Shuttle Vector for Use in Studies of Transcription-coupled DNA Repair This summer, I have had the incredible opportunity of working with ___ under the direct mentorship of ___ on designing, constructing and analyzing a single-lesion containing shuttle vector to be used for studies of transcription-coupled DNA repair (TCR). This experience has provided me with insight into the logic behind genetic engineering and experiment design and given me greater aptitude in various laboratory procedures including RT-PCR (reverse transcriptase polymerase chain reaction), plasmid transfection and recovery, plasmid transformation and amplification, and RNA isolation. It was the creativity of the design-associated aspects of our project that I found most satiating. In fact, in order to keep up with the evolution of the construction design, I learneda good deal of interesting biology that I now find the most valuable aspect of my internship. Enthusiastic about the knowledge I have gained while spending my days at the Cooper lab, I feel compelled to write this web-page with a focus that emphasizes the progression of my understanding about TCR and single-lesion containing shuttle vectors while it describes the experiments and protocol optimizations I performed. AbstractOur goal is to design a shuttle vector that contains a unique, site-specific lesion in order to study transcription-coupled repair of human DNA. In our system, the lesion is introduced by insertion of a synthesized 8-oxoguanine-containing oligomer into a pS189-derived plasmid at either of two locations: within the t-antigen (Tag) intron 400 bases beyond the ATG translation start codon, or at the end of the Tag, after the polyadenylation signal. The pS189 shuttle vector was modified to increase the transcription frequency of the Tag, prevent plasmid replication, and distinguish between Tag derived from SV40-transformed cells and that from the shuttle vector. Initial studies were undertaken to optimize the transfection conditions and also to verify the various plasmid alterations. Preliminary RT-PCR of mRNA harvested 24 hours after plasmid transfection has demonstrated that use of primers tuned to the Tag modifications do successfully distinguish plasmid from cellular RNA. Replication assays using methylation-sensitive endonucleases have verified the competence of engineered mutations in the SV40 ori in achieving preclusion of plasmid replication. RT-PCR has also shown low amplification near the Bgl II site, suggesting its removal during the processing of mature mRNA. It will therefore be necessary to construct a new site for lesion insertion before the poly-adenylation signal. In conclusion, with the competency of the pS189-derived plasmids confirmed by RT-PCR, both the shuttle vector and the transfection protocol have been optimized for TCR studies, and we are ready to insert the 8-oxoG-containing oligomer. IntroductionToward maintenance of genomic integrity and to combat the mutations and genetic degradation associated with aging and cancer, several intricate and interconnected pathways exist for DNA repair. These repair pathways include nucleotide excision repair (NER) and base excision repair (BER). Excision and repair of lesions on the transcribed strand (TS) occurs at a higher frequency than on the non-transcribed strand (NTS). This phenomenon called transcription-coupled repair (TCR) seems to be initiated by RNA polymerase II stalled at lesions or lesion-protein complexes. Lesions introduced by reactive oxygen species generated during cellular metabolism, including 8-oxoguanine (8-oxoG), are subject to TCR, even though they do not impede DNA polymerase during replication. If left unrepaired, 8-oxoG lesions can mispair with adenine and, upon replication, cause a guanine to thymine transversion with 50% frequency. Impedance of TCR results in a degenerative disease, Cockayne Syndrome (CS), characterized by postnatal developmental failure, neurological degeneration and early death. Another disease, Xeroderma Pigmentosum (XP), involves the global malfunction of nucleotide-excision repair (NER) due to mutations in the XPA-XPG proteins. Previously, investigators introduced oxidative lesions in a random, stochastic manner, making the detailed kinetics of TCR difficult to assay. .u4ec2d6ecb734c6d9b46b4d2362d6dfd5 , .u4ec2d6ecb734c6d9b46b4d2362d6dfd5 .postImageUrl , .u4ec2d6ecb734c6d9b46b4d2362d6dfd5 .centered-text-area { min-height: 80px; position: relative; } .u4ec2d6ecb734c6d9b46b4d2362d6dfd5 , .u4ec2d6ecb734c6d9b46b4d2362d6dfd5:hover , .u4ec2d6ecb734c6d9b46b4d2362d6dfd5:visited , .u4ec2d6ecb734c6d9b46b4d2362d6dfd5:active { border:0!important; } .u4ec2d6ecb734c6d9b46b4d2362d6dfd5 .clearfix:after { content: ""; display: table; clear: both; } .u4ec2d6ecb734c6d9b46b4d2362d6dfd5 { display: block; transition: background-color 250ms; webkit-transition: background-color 250ms; width: 100%; opacity: 1; transition: opacity 250ms; webkit-transition: opacity 250ms; background-color: #95A5A6; } .u4ec2d6ecb734c6d9b46b4d2362d6dfd5:active , .u4ec2d6ecb734c6d9b46b4d2362d6dfd5:hover { opacity: 1; transition: opacity 250ms; webkit-transition: opacity 250ms; background-color: #2C3E50; } .u4ec2d6ecb734c6d9b46b4d2362d6dfd5 .centered-text-area { width: 100%; position: relative ; } .u4ec2d6ecb734c6d9b46b4d2362d6dfd5 .ctaText { border-bottom: 0 solid #fff; color: #2980B9; font-size: 16px; font-weight: bold; margin: 0; padding: 0; text-decoration: underline; } .u4ec2d6ecb734c6d9b46b4d2362d6dfd5 .postTitle { color: #FFFFFF; font-size: 16px; font-weight: 600; margin: 0; padding: 0; width: 100%; } .u4ec2d6ecb734c6d9b46b4d2362d6dfd5 .ctaButton { background-color: #7F8C8D!important; color: #2980B9; border: none; border-radius: 3px; box-shadow: none; font-size: 14px; font-weight: bold; line-height: 26px; moz-border-radius: 3px; text-align: center; text-decoration: none; text-shadow: none; width: 80px; min-height: 80px; background: url(https://artscolumbia.org/wp-content/plugins/intelly-related-posts/assets/images/simple-arrow.png)no-repeat; position: absolute; right: 0; top: 0; } .u4ec2d6ecb734c6d9b46b4d2362d6dfd5:hover .ctaButton { background-color: #34495E!important; } .u4ec2d6ecb734c6d9b46b4d2362d6dfd5 .centered-text { display: table; height: 80px; padding-left : 18px; top: 0; } .u4ec2d6ecb734c6d9b46b4d2362d6dfd5 .u4ec2d6ecb734c6d9b46b4d2362d6dfd5-content { display: table-cell; margin: 0; padding: 0; padding-right: 108px; position: relative; vertical-align: middle; width: 100%; } .u4ec2d6ecb734c6d9b46b4d2362d6dfd5:after { content: ""; display: block; clear: both; } READ: Frees: Black Success through Hard Work or Af Essay These limitations can be surpassed with the constructing of site-specific single-lesion containing shuttle vectors. Our Research GoalsTo study transcription-coupled repair of oxidative damage to DNA in various cell lines from Cockayne Syndrome (CS) and Xeroderma Pigmentosum (XP) patients, using a single-lesion containing shuttle vector. To further characterize both the requirements for XPD/XPB/XPG in TCR, and the behavior of RNA Polymerase near oxidative lesions. To further assess the degree to which lesions caused by oxidative damage (specifically

Isolated Families

While researchers consider poverty to be a primary reason for isolation, all individuals who are unable to participate socially or integrate themselves into the social realm, or without the necessary tools of power could be at a risk for isolation (Hayes, Gray Edwards, 2008).Advertising We will write a custom essay sample on Isolated Families – Australia specifically for you for only $16.05 $11/page Learn More Members of some community could face isolation as a result of living in remote neighborhoods which enjoy fewer benefits as compared to those with sufficient resources for education and employment (Hayes et al., 2008). Vinson (2007) explicates that community members belonging to low income groups and living in localities with limited resources such as education, health and labor are at a higher risk for isolation. Novello et al. (2011) note the impact of families and couples living with a partner suffering from a mental health problems or dis tress. Hayes (2007) found that low levels of parental education, family problems, child abuse in families, failure of children in schools are important aspects which lead to social isolation in children. In his report, Vinson (2007) proposes government sponsored community projects and intervention plans to reduce social exclusion. He recommends implementation of these projects over longer periods of time rather than short doses. He asserts that there should be a greater focus on education, better job opportunities, job placements, enhanced resources for health and treatment, development and training of parenting skills and the development of local leadership. Social capital has been defined as the availability of networks and access to social connectedness within a community (Stone, 2001). Since my community has a good transportation system, communication system including telephone exchanges, mobile phone companies, schools, churches, recreational activity centers such as sports clu bs, Disney parks etc., I would rate it high on the social capital scale. The Internet provides new opportunities for social connection for people who are isolated. Access to the internet has been identified as an important economic barrier to social inclusion (Vinson, 2007). Childhood services could serve as informational centers and communication networking centers for parents (Grace Bowes, 2010).Advertising Looking for essay on education? Let's see if we can help you! Get your first paper with 15% OFF Learn More Staff members of these centers could work towards the facilitation of communication between parents of children with special needs and professional child experts (Grace Bowes, 2010). Staff members of child service teams could provide parents with knowledge and information for enhanced interaction and communication with children (Grace Bowes, 2010). References Grace, R. Bowes, J. (2010). Barriers to Participation: The Experience of Disadvantaged Young Chil dren, their Families, and Professionals in Engaging with Early Childhood Services. Web. Hayes, A., Gray, M., Edwards, B. (2008). Social inclusion: Origins, concepts and key themes. Canberra: Commonwealth of Australia. Novello, D. J., Stain, H. J., Lyle, D. Kelly, B. J. (2011). Psychological distress of rural parents: Family influence and the role of isolation. Journal of Rural Health, 19 (1), 27-31. Stone, W. (2001). Measuring social capital: Towards a theoretically informed measurement framework for researching social capital in family and community life (Research Paper No. 24). In Hayes, A., Gray, M., Edwards, B. (2008). Social inclusion: Origins, concepts and key themes. Canberra: Commonwealth of Australia. Vinson, T. (2007). Dropping Off the Edge: The Distribution of Disadvantage in Australia. Canberra: Catholic Social Services Australia. Posting Response We are indeed fortunate to be living in a good community setting which facilitates social inclusion. Since we rank high on the social capital scale, we have better opportunities to interact, socialize and gain education. All of these factors increase the potential for better jobs, social networking and an overall better life.Advertising We will write a custom essay sample on Isolated Families – Australia specifically for you for only $16.05 $11/page Learn More Since an advantageous neighborhood has been noted as an important factor in social capital (Vinson, 2007), we should focus on strategies which will help us improve neighborhoods of the less fortunate children. Childhood services could indeed play an important part in making neighborhoods more advantageous (Grace Bowes, 2010). The staff of these childhood services should be appropriately trained for educating parents about ways to communicate with children. Additionally, childhood services should serve as platforms for social interaction between parents, thereby reducing levels of social isolation between fami lies. By holding meetings and events which involve parents and children, childhood services could achieve the goal of social inclusion. In absolutely remote areas where parents and families have less access to transport and means of communication, childhood service centers could set up internet hubs to encourage social networking. Networking and communication will surely be easier with access to the internet. However, parents should be educated about the importance of extra curricular activities for children in aiding their overall growth and development. Since lack of community activities and hobbies have been noted as an important measure of social exclusion (Hayes, Gray Edwards, 2008), child services should take the responsibility of setting up events and programs which promote and encourage children and parents to participate in social activities. This essay on Isolated Families – Australia was written and submitted by user Iman1 to help you with your own studies. You are free to use it for research and reference purposes in order to write your own paper; however, you must cite it accordingly. You can donate your paper here.

Using Metaphors and Similes Effectively - Writing Tips

Using Metaphors and Similes Effectively - Writing Tips Similes and metaphors can be used to convey ideas as well as offer striking images. Consider the simile in the first sentence below and the extended metaphor in the second: Her mind was like a balloon with static cling, attracting random ideas as they floated by.(Jonathan Franzen, Purity. Farrar, Straus Giroux, 2015)I am a camera with its shutter open, quite passive, recording, not thinking. Recording the man shaving at the window opposite and the woman in the kimono washing her hair. Some day, all this will have to be developed, carefully printed, fixed.(Christopher Isherwood, The Berlin Stories. New Directions, 1945) Metaphors and similes can not only make our writing more interesting but also help us think more carefully about our subjects. Put another way, metaphors and similes arent just fanciful expressions or pretty ornaments; they are ways of thinking. So how do we begin to create metaphors and similes? For one thing, we should be ready to play with language and ideas. A comparison like the following, for example, might appear in an early draft of an essay: Laura sang like an old cat. As we revise our draft, we might try adding more details to the comparison to make it more precise and interesting: When Laura sang, she sounded like a cat sliding down a chalkboard. Be alert to the ways in which other writers use similes and metaphors in their work. Then, as you revise your own paragraphs and essays, see if you can make your descriptions more vivid and your ideas clearer by creating original similes and metaphors. Practice Using Similes and Metaphors Heres an exercise that will give you some practice in creating figurative comparisons. For each of the statements below, make up a simile or a metaphor that helps to explain each statement and make it more vivid. If several ideas come to you, jot them all down. When youre done, compare your response to the first sentence with the sample comparisons at the end of the exercise. George has been working at the same automobile factory six days a week, ten hours a day, for the past twelve years.(Use a simile or a metaphor to show how worn out George was feeling.)Katie had been working all day in the summer sun.(Use a simile or a metaphor to show how hot and tired Katie was feeling.)This is Kim Sus first day at college, and she is in the middle of a chaotic morning registration session.(Use a simile or a metaphor to show either how confused Kim feels or how chaotic the entire session is.)Victor spent his entire summer vacation watching quiz shows and soap operas on television.(Use a simile or a metaphor to describe the state of Victors mind by the end of his vacation.)After all the troubles of the past few weeks, Sandy felt peaceful at last.(Use a simile or a metaphor to describe how peaceful or relieved Sandy was feeling.) Sample Responses to Sentence #1 a. George felt as worn out as the elbows on his work shirt.b. George felt as worn out as his deeply scuffed work boots.c. George felt worn out, like an old punching bag in a neighbors garage.d. George felt as worn out as the rusted Impala that carried him to work every day.e. George felt as worn out as an old joke that was never very funny in the first place.f. George felt worn out and uselessjust another broken fan belt, a burst radiator hose, a stripped wing nut, a discharged battery.

See Asignment criteria- request for writer 5689 of possible Essay

See Asignment criteria- request for writer 5689 of possible - Essay Example sidered the height of the romantic manifestation with regard to the [Spanish] stage,’ explicitly references its central theme of Destiny in the title – ‘la fuerza del sino’ as it applies to the struggle and ultimate defeat of the protagonist (Young 1933, 278). Within the typical Sturm und Drang Romantic expression, Rivas utilises a conception of ‘fate’ to explore and undermine the obsolescing social hierarchy that dominated contemporary Spanish life. Yet the question remains unclear: what exactly is the nature, the driving force of this conceived destiny? Does this demonstrate the movement of divine providence, or is this more akin to the fatalistic destiny of the Greeks? As the story progresses, the thread of fate that propels the action reveals itself to be profoundly fatalistic, not the orchestration of an omnipotent God but the engine of the myriad unseen forces that surround and enshround Don à lvaro in his journey through despair. This fatalism draws its roots most profoundly from the tradition of Greek tragedy in which destiny always played a primary role. Yet Rivas develops advances on this fatalistic tradition, showing through the random twists delivered by destiny’s hand the massively destructive forces of the familial Spanish hierarchy, which from the beginning envelop the protagonist in the shackles of old custom. It is these, Rivas declares audaciously through his play, that make up the very essence of dest iny. It is these, the forces of society, which create the fatalistic reality in which all his characters, and by extension the whole of Spanish populiation, are doomed to their allotted existence. The fatalistic concept fundamental to Greek tragedy is the act of transgression, the fatal flaw caused by hubris, or believing oneself to be above divine law, which transgression in the protagonist’s own demise. This act of transgression could be something as active as Prometheus’ theft of divine fire, for which he was savagely

An Exploration of the Attributes of Organized Crime Research Paper

An Exploration of the Attributes of Organized Crime - Research Paper Example n American countries like Mexico and Colombia are commonly regarded as organized crime aspects as they explicitly violet the legal administrations of the respective countries so as to gain monetary wise. Some of the international organizations referred to as the mafias include the Albanian Mafia, the Black Mafia, the Russian Mafia, the Japanese Yakuza and the Chinese Triads (Abadinsky, 2010). The United States Organized Crime Control Act in 1970 defines organized crime as an unlawful activity carried out by highly organized and disciplined association. Statistics have it that the number of people involved in organized crime in the United Kingdom is approximated to be over 38, 000 involving more than 6000 groups (Haller, 1991). Organized crime is normally associated with several illegal activities such as illegal gambling, assassination, bombing, blackmailing, oil smuggling and arms trafficking. This type of crime also has extreme effects on political corruption mostly in areas experiencing political instability like the Middle East. Such criminal organizations are normally associated with large amounts of money some of which is used to bribe government officials in an effort to avoid prosecution. Organized crime has also been linked with massive roles in people smuggling and human trafficking. The Yamaguchi-Gumi, the Russian Mafia and the ‘Ndrangheta have been identified as the most powerful and prolific organized crime groups all over the world (O’Kane, 1992). Despite the Russian being the largest criminal group, the main problem being faced by the existing law enforcement is its ability to point out the members of such organizations now that most people engage in organized crime activities claiming they are members of these mafia groups yet in the real sense they are out to gain respect and spread fear. Latin America has been identified as the base to the most violent and influential drug cartels all over the world. This area has been heavily associated

Womens’ Compulsive Obsession Essay Example for Free

Womens’ Compulsive Obsession Essay In â€Å"A Woman’s Beauty: Put Down or Power Source?† Susan ​ Sontag  ­ argues that women view beauty as an obligation and that they actually focus on their appearance more than who they are as a person. In the essay, Sontag provides the perspectives of both Christians and Greeks towards beauty and compares them to the superficial views of the present. Sontag stresses that women should direct their attention to other things rather than beauty. Beauty is put at such a high standard that women feel the need to be as beautiful as the women advertised. Basically, women endeavor to be appropriate and beautiful to attract men. Sontag also showcases that women believe that being beautiful will earn them a reputation and place in society, and that beauty brings power and success. According to Sontag, beauty is the only form of power that women are encouraged to seek. In our own time, beauty is administered as a form of self ­oppression. In the process of growing up, young women may forget how intelligent they are and their aspirations in life. A woman’s success in the society s depends on good looks, which are a great advantage in life.

Childhood Obesity Essay -- Health, Diseases, Overweight

The World Health Organization (2006, WHO) defines obesity as a body mass index (weight-for-height) equal to or more than 30. In the UK the prevalence of obesity in childhood has significantly increased over the past twenty five years. A study commissioned by The Health Survey for England (HSE) showed that between 1996 and 2001 the proportion of obese children aged six to fifteen rose by 3.5 per cent from 20 per cent to 23.5 per cent of the population in that age bracket; there is no reason to suspect that the children of England are not representative of the United Kingdom as a whole. Concern has grown that because of this increase obesity-related diseases, such as diabetes and heart disorders, will, in due course, occur in more adults than at present and that they will be diagnosed at a much earlier age. There has been strong government action to address the problem of childhood obesity, most notably as one of the five outcomes sought within Every Child Matters (DfES,2003,ECM). This was established in 2004 by the Department of Children, Schools and Families, with the intention of working together with other with other children’s services in order to approach and promote the well being of children. Further evidence is becoming available of more detailed analyses of the incidence of obesity by age, sex and geographical region. Using graph (i) below, produced for the National Child Measurement Programme from the NHS Information Centre (2009), we can see that the percentages of children falling into the â€Å"underweight†, â€Å"overweight† and â€Å"obese† categories remain generally stable over the three years reviewed, except that there was an increase of just over 1% in the â€Å"obese† category between 2006/07 and 2008/09. It is, however, disturb... ...iet and therefore stronger government action and funding would be needed in order to reverse the current trend. Moreover, parents need to be more aware as there is evidence from the Forecasting Obesity 2010 (2006) documents that suggest that for both boys and girls, a significant number of children who live with parents who are classified as overweight or obese tended to be obese themselves. Little evidence is yet to suggest a high success rate, although Jamie Oliver has had a relevant impact on healthy food within the school environment. This could eventually, therefore, show a stabilisation of percentage of obese children. Nevertheless, this is based on limited data over a three year period and for this to be established, or even improved, there needs to be several more years of relevant data to prove that this is, in fact, a trend rather than a periodical error.

The Host Chapter 58: Finished

I was so tightly wound that I shrieked in terror; I was so terrified that my shriek was only a breathless little squeal. â€Å"Sorry!† Jared's arm went around my shoulders, comforting. â€Å"I'm sorry. I didn't mean to scare you.† â€Å"What are you doing here?† I demanded, still breathless. â€Å"Following you. I've been following you all night.† â€Å"Well, stop it now.† There was a hesitation in the dark, and his arm didn't move. I shrugged out from under it, but he caught my wrist. His grip was firm; I wouldn't be able to shake free easily. â€Å"You're going to see Doc?† he asked, and there was no confusion in the question. It was obvious that he wasn't talking about a social visit. â€Å"Of course I am.† I hissed the words so that he wouldn't hear the panic in my voice. â€Å"What else can I do after today? It's not going to get any better. And this isn't Jeb's decision to make.† â€Å"I know. I'm on your side.† It made me angry that these words still had the power to hurt me, to bring tears stinging into my eyes. I tried to hold on to the thought of Ian-he was the anchor, as Kyle somehow had been for Sunny-but it was hard with Jared's hand touching me, with the smell of him in my nose. Like trying to make out the song of one violin when the entire percussion section was bashing away†¦ â€Å"Then let me go, Jared. Go away. I want to be alone.† The words came out fierce and fast and hard. It was easy to hear that they weren't lies. â€Å"I should come with you.† â€Å"You'll have Melanie back soon enough,† I snapped. â€Å"I'm only asking for a few minutes, Jared. Give me that much.† Another pause; his hand didn't loosen. â€Å"Wanda, I would come to be with you.† The tears spilled over. I was grateful for the darkness. â€Å"It wouldn't feel that way,† I whispered. â€Å"So there's no point.† Of course Jared could not be allowed to be there. Only Doc could be trusted. Only he had promised me. And I wasn't leaving this planet. I wasn't going to go live as a Dolphin or a Flower, always grieving for the loves I'd left behind me, all dead by the time I opened my eyes again-if I even had eyes. This was my planet, and they wouldn't make me leave. I would stay in the dirt, in the dark grotto with my friends. A human grave for the human I had become. â€Å"But Wanda, I†¦ There's so much that I need to say to you.† â€Å"I don't want your gratitude, Jared. Trust me on that.† â€Å"What do you want?† he whispered, his voice strained and choked. â€Å"I would give you anything.† â€Å"Take care of my family. Don't let the others kill them.† â€Å"Of course I'll take care of them.† He dismissed my request brusquely. â€Å"I meant you. What can I give you?† â€Å"I can't take anything with me, Jared.† â€Å"Not even a memory, Wanda? What do you want?† I brushed the tears away with my free hand, but others took their place too quickly for it to matter. No, I couldn't take even a memory. â€Å"What can I give you, Wanda?† he insisted. I took a deep breath and tried to keep my voice steady. â€Å"Give me a lie, Jared. Tell me you want me to stay.† There was no hesitation this time. His arms wound around me in the dark, held me securely against his chest. He pressed his lips against my forehead, and I felt his breath move my hair when he spoke. Melanie was holding her breath in my head. She was trying to bury herself again, trying to give me my freedom for these last minutes. Maybe she was afraid to listen to these lies. She wouldn't want this memory when I was gone. â€Å"Stay here, Wanda. With us. With me. I don't want you to go. Please. I can't imagine having you gone. I can't see that. I don't know how to†¦ how to†¦Ã¢â‚¬  His voice broke. He was a very good liar. And he must have been very, very sure of me to say those things. I rested against him for a moment, but I could feel the time pulling me away. Time was up. Time was up. â€Å"Thank you,† I whispered, and I tried to extricate myself. His arms tightened. â€Å"I'm not done.† Our faces were only inches apart. He closed the distance, and even here, on the edge of my last breath on this planet, I couldn't help responding. Gasoline and an open flame-we exploded again. It wasn't the same, though. I could feel that. This was for me. It was my name that he gasped when he held this body-and he thought of it as my body, thought of it as me. I could feel the difference. For one moment, it was just us, just Wanderer and Jared, both of us burning. No one had ever lied better than Jared lied with his body in my last minutes, and for that I was grateful. I couldn't take it with me, because I wasn't going anywhere, but it eased some of the pain of leaving. I could believe the lie. I could believe that he would miss me so much that it might even mar some of his joy. I shouldn't want that, but it felt good to believe it anyway. I couldn't ignore the time, the seconds ticking like a countdown. Even on fire, I could feel them dragging at me, sucking me down the dark corridor. Taking me away from all this heat and feeling. I managed to pull my lips away from his. We panted in the dark, our breath warm on each other's faces. â€Å"Thank you,† I said again. â€Å"Wait†¦Ã¢â‚¬  â€Å"I can't. I can't†¦ bear any more. Okay?† â€Å"Okay,† he whispered. â€Å"I just want one more thing. Let me do this alone. Please?† â€Å"If†¦ if you're sure that's what you want†¦Ã¢â‚¬  He trailed off, unsure. â€Å"It's what I need, Jared.† â€Å"Then I'll stay here,† he said hoarsely. â€Å"I'll send Doc to get you when it's over.† His arms were still locked around me. â€Å"You know that Ian is going to try to kill me for letting you do this? Maybe I should let him. And Jamie. He'll never forgive either of us.† â€Å"I can't think about them right now. Please. Let me go.† Slowly, with a palpable reluctance that warmed some of the cold emptiness in the center of my body, Jared let his arms slide away. â€Å"I love you, Wanda.† I sighed. â€Å"Thanks, Jared. You know how much I love you. With my whole heart.† Heart and soul. Not the same thing, in my case. I'd been divided too long. It was time to make something whole again, make a whole person. Even if that excluded me. The ticking seconds pulled me toward the end. It was cold when he no longer held me. It got colder every step I took away from him. Just my imagination, of course. It was still summer here. It would always be summer here for me. â€Å"What happens here when it rains, Jared?† I whispered. â€Å"Where do people sleep?† It took him a moment to answer, and I could hear tears in his voice. â€Å"We†¦Ã¢â‚¬  He swallowed. â€Å"We all move into the game room. Everyone sleeps in there together.† I nodded to myself. I wondered what the atmosphere would be like. Awkward, with all the conflicting personalities? Or was it fun? A change? Like a slumber party? â€Å"Why?† he whispered. â€Å"I just wanted to†¦ imagine. How it will be.† Life and love would go on. Even though it would happen without me, the idea brought me joy. â€Å"Goodbye, Jared. Mel says she'll see you soon.† Liar. â€Å"Wait†¦ Wanda†¦Ã¢â‚¬  I hurried down the tunnel, hurried away from any chance that he might, with his grateful lies, convince me not to go. There was only silence behind me. His pain did not hurt me the way Ian's had. For Jared, pain would be over soon. Joy was only minutes away. The happy ending. The southern tunnel felt only a few yards long. I could see the bright lantern burning ahead, and I knew Doc was waiting for me. I walked into the room that had always frightened me with my shoulders squared. Doc had everything prepared. In the dimmest corner, I could see two cots pushed together, Kyle snoring with his arm around Jodi's motionless form. His other arm was still curled around Sunny's tank. She would have liked that. I wished there was some way to tell her. â€Å"Hey, Doc,† I whispered. He looked up from the table where he was setting out the medicine. There were already tears streaming down his face. And suddenly, I was brave. My heart slowed to an even pace. My breath deepened and relaxed. The hardest parts were over. I had done this before. Many times. I had closed my eyes and gone away. Always knowing new eyes would open again, but still. This was familiar. Nothing to fear. I went to the cot and hopped up so that I was sitting on it. I reached for the No Pain with steady hands and screwed the lid off. I put the little tissue square on my tongue, let it dissolve. There was no change. I wasn't in any pain this time. No physical pain. â€Å"Tell me something, Doc. What's your real name?† I wanted to answer all the little puzzles before the end. Doc sniffed and wiped the back of his hand under his eyes. â€Å"Eustace. It's a family name, and my parents were cruel people.† I laughed once. Then I sighed. â€Å"Jared's waiting, back by the big cave. I promised him you'd tell him when it was over. Just wait until I-until I†¦ stop moving, okay? It will be too late for him to do anything about my decision then.† â€Å"I don't want to do this, Wanda.† â€Å"I know. Thanks for that, Doc. But I'm holding you to your promise.† â€Å"Please?† â€Å"No. You gave me your word. I did my part, didn't I?† â€Å"You did.† â€Å"Then do yours. Let me stay with Walt and Wes.† His thin face worked as he tried to keep back a sob. â€Å"Will you be†¦ in pain?† â€Å"No, Doc,† I lied. â€Å"I won't feel anything.† I waited for the euphoria to come, for the No Pain to set everything glowing the way it had the last time. I still didn't feel any difference. It must not have been the No Pain after all-it had just been being loved. I sighed again. I stretched out on the cot, on my stomach, and turned my face toward him. â€Å"Put me under, Doc.† The bottle opened. I heard him shake it onto the cloth in his hand. â€Å"You are the noblest, purest creature I've ever met. The universe will be a darker place without you,† he whispered. These were his words over my grave, my epitaph, and I was glad that I got to hear them. Thank you, Wanda. My sister. I will never forget you. Be happy, Mel. Enjoy it all. Appreciate it for me. I will, she promised. Bye, we thought together. Doc's hand pressed the cloth gently over my face. I breathed in deeply, ignoring the thick, uncomfortable scent. As I took another breath, I saw the three stars again. They were not calling to me; they were letting me go, leaving me to the black universe I had wandered for so many lifetimes. I drifted into the black, and it got brighter and brighter. It wasn't black at all-it was blue. Warm, vibrant, brilliant blue†¦ I floated into it with no fear at all.

Early Childhood Development A Social And Cultural...

The life course approach analyzes the life of an individual within a social and cultural context (Maggi 2010). It is important to understand these structures as they aid in determining what makes wealthy societies healthier than others. Early child development determines future health outcomes through latent, pathway and cumulative effects. Factors such as family, education, socio-economic status and exposure to disease influence a child’s development. This paper represents a critical analysis of the implications of this approach associated with early childhood development. I will first give you my view on this social phenomenon following the social gradient and how it is manifested in this life stage. I will then discuss the implication that could help improve health in early childhood. I have witnessed domestic violence among family members at a very young age. I remember the police being called to my house during the night to check up when my mom would call 911 in a scare. I remember my parents yelling at each other about finances, childcare, food supply, as they alternated holding me as a child as I cry. As I got older my feelings towards the situation changed where I wouldn’t sleep at night incase the violence would reoccur, I would go to school with a constant stomach ache which prevented me from eating or even feeling hungry. The one thing I found came easy, due to my personality, was to shut down and not show my emotions to anyone nor did I show the way my body